Hydrochloric Acid → HCID 19895736, compound

HRID 1579549Notes

Reaction equation

HRID 1579549 reaction equation
[CH3:1][N:2]([CH3:28])[CH2:3][CH2:4][C:5]1[NH:6][C:7]2[C:12]([C:13]=1[CH2:14][C:15]1([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:20][CH2:19][CH2:18][CH2:17][C:16]1=[O:21])=[CH:11][CH:10]=[CH:9][CH:8]=2.[ClH:29].[CH3:30]COCC>>[ClH:29].[CH3:28][N:2]([CH3:1])[CH2:3][CH2:4][C:5]1[N:6]([CH3:30])[C:7]2[C:12]([C:13]=1[CH2:14][C:15]1([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:20][CH2:19][CH2:18][CH2:17][C:16]1=[O:21])=[CH:11][CH:10]=[CH:9][CH:8]=2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 21568734HCID 21568734, compound

Product 1

HCID 19895736HCID 19895736, compound

Procedure

The same procedure was used to methylate 37.5 g (0.1 mol) of 2({2-[2-(dimethylamino)ethyl]indol-3-yl}methyl)-2-phenylcyclohexanone. The residue obtained on evaporation of the ethereal extraction solvent was redissolved in ether and treated with ethereal hydrogen chloride. The crude hydrochloride salt was collected and recrystallized from 750 ml of isopropyl alcohol to give 25.8 g of product, mp 246°-247°dec.

Workup

  1. customThe residue obtained on evaporation of the ethereal extraction solvent
  2. customThe crude hydrochloride salt was collected
  3. customrecrystallized from 750 ml of isopropyl alcohol

Sources & evidence

ORD record
ord-91c74c5d0ea74117b379b3b147518bec
Source dataset
uspto-grants-1976_01
Patent number
US03931230

Reaction notes

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