反应详情

A solution of 1.7 g. of 3-(1,2-dimethylheptyl)-5,6,7,8-tetrahydro-1-hydroxy-6,9-dimethylxanthene in 70 ml. of p-cymene is added dropwise over one hour to a stirred suspension of 0.56 g. of 10% palladium-on-carbon in 70 ml. of refluxing p-cymene under a nitrogen atmosphere. The reaction mixture is refluxed for four hours, cooled and chloroform is added. The mixture is filtered and the filtrate is concentrated in vacuo to give a residue which is chromatographed on silica gel with 1:1 chloroform-cyclohexane as eluant to give the title compound, b.p. 208°-210° (0.004 mm.).

1. temperatureThe reaction mixture is refluxed for four hours
2. temperaturecooled
3. filtrationThe mixture is filtered
4. concentrationthe filtrate is concentrated in vacuo
5. customto give a residue which
6. customis chromatographed on silica gel with 1:1 chloroform-cyclohexane as eluant