Methanol → (Z)-tert-butyl 3-(3-hydroxypropyl)-6-(8-(3-((2-(trimethylsilyl)ethoxy)methyl)benzo[d]thiazol-2(3H)-ylidenecarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinate
Reaction equation
[BH4-:48].[CH2:50]1[O:51][CH2:52][CH2:53][CH2:54]1.[CH3:55][OH:56].[Na+:49].[O:1]=[CH:2][CH2:3][CH2:4][c:5]1[c:6]([C:41](=[O:42])[O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[n:7][c:8]([N:11]2[CH2:12][c:13]3[c:14]([C:21]([N:22]=[c:23]4[s:24][c:25]5[c:26]([n:27]4[CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:33])([CH3:34])[CH3:35])[cH:36][cH:37][cH:38][cH:39]5)=[O:40])[cH:15][cH:16][cH:17][c:18]3[CH2:19][CH2:20]2)[cH:9][cH:10]1>>[OH:1][CH2:2][CH2:3][CH2:4][c:5]1[c:6]([C:41](=[O:42])[O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[n:7][c:8]([N:11]2[CH2:12][c:13]3[c:14]([C:21]([N:22]=[c:23]4[s:24][c:25]5[c:26]([n:27]4[CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:33])([CH3:34])[CH3:35])[cH:36][cH:37][cH:38][cH:39]5)=[O:40])[cH:15][cH:16][cH:17][c:18]3[CH2:19][CH2:20]2)[cH:9][cH:10]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-611c0706f20a4353b025a63ff857791f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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