Ammonia → 2,6-Dimethylaniline
Reaction equation
[NH3:1].C1(=O)CCCCC1.[H][H].[CH3:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[C:13]=1O>[Pd].O>[CH3:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[C:13]=1[NH2:1]Participants
7
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Procedure
Hydroxy aromatics are aminated to form the corresponding aromatic amine by reaction at 200°-400°C with ammonia in the presence of a cyclohexanone and water in contact with a hydrogen transfer catalyst. For example, 2,6-dimethylphenol reacts with ammonia in the presence of cyclohexanone, water and a supported palladium catalyst to form 2,6-dimethylaniline.
Sources & evidence
- ORD record
- ord-941b3fa9ac8e4911ae94a6a7963d6207
- Source dataset
- uspto-grants-1976_01
- Patent number
- US03931298
Reaction notes
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