反应详情

4.10 g (0.020 mole) of 3-methyl-5-[2,6,6-trimethyl-cyclohex-2-en-1-yl]-isoxazole were dissolved in 5 ml of anhydrous ethanol and the solution was added to 0.173 g of a mixture of 83.6% of platinum oxide in 30 ml of ethanol, the said mixture having previously been subjected to a hydrogenation. The solution was then subjected to a hydrogenation at room temperature and at atmospheric pressure and, after absorption of one equivalent of hydrogen, filtered through a "Celite" carrier. After having been concentrated under reduced pressure the residual solution was subjected to chromatography on a magnesium silicate column by elution with a mixture of chloroform/hexane (25/75) to yield 3.73 g (yield: 90%) of 2,6,6-trimethyl-1-[3-amino-but-2-enoyl]-cyclohex-2-ene.

1. customwas then subjected to a hydrogenation at room temperature and at atmospheric pressure
2. filtrationfiltered through a "Celite" carrier
3. concentrationAfter having been concentrated under reduced pressure the residual solution
4. washwas subjected to chromatography on a magnesium silicate column by elution with a mixture of chloroform/hexane (25/75)