3-Methyl-5-(2,6,6-trimethylcyclohex-2-en-1-yl)-1,2-oxazole → HCID 68134272, compound

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Reaction Steps

4.10 g (0.020 mole) of 3-methyl-5-[2,6,6-trimethyl-cyclohex-2-en-1-yl]-isoxazole were dissolved in 5 ml of anhydrous ethanol and the solution was added to 0.173 g of a mixture of 83.6% of platinum oxide in 30 ml of ethanol, the said mixture having previously been subjected to a hydrogenation. The solution was then subjected to a hydrogenation at room temperature and at atmospheric pressure and, after absorption of one equivalent of hydrogen, filtered through a "Celite" carrier. After having been concentrated under reduced pressure the residual solution was subjected to chromatography on a magnesium silicate column by elution with a mixture of chloroform/hexane (25/75) to yield 3.73 g (yield: 90%) of 2,6,6-trimethyl-1-[3-amino-but-2-enoyl]-cyclohex-2-ene.

Provenance & Evidence