反应详情

A mixture of 0.167 moles of the ethyl α-chloro-6-methoxy-2-naphthylacetate and 160 ml. of glacial acetic acid containing 40 ml. of 37% hydrochloric acid is refluxed for 20 hours. The mixture is concentrated under reduced pressure to give a gummy residue. The latter material is dissolved in 300 ml. of n-hexane, washed with ice-cold water (100 ml. total), dried over sodium sulfate and filtered. The hexane is removed to give α-chloro-6-methoxy-2-naphthylacetic acid.

1. concentrationThe mixture is concentrated under reduced pressure
2. customto give a gummy residue
3. dissolutionThe latter material is dissolved in 300 ml
4. washof n-hexane, washed with ice-cold water (100 ml. total)
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. customThe hexane is removed