Hydrochloric Acid → HCID 21569107, compound

HRID 1579836Notes

Reaction equation

HRID 1579836 reaction equation
Cl[CH:2]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:16][CH3:17])[CH:12]=2)[CH:7]=1)[C:3]([OH:5])=[O:4].[SH-:18].[Na+].Cl>>[SH:18][CH:2]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:16][CH3:17])[CH:12]=2)[CH:7]=1)[C:3]([OH:5])=[O:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 28015Sodium hydrosulfideHCID 21569134HCID 21569134, compound

Product 1

HCID 21569107HCID 21569107, compound

Procedure

A mixture of 0.05 moles of α-chloro-6-methoxy-2-naphthylacetic acid and 5 g. of sodium hydrosulfide in 100 ml. of absolute ehtanol and under a nitrogen atmosphere is stirred for 15 hours. The mixture is then acidified with 6 N hydrochloric acid. The solvent is removed in vacuo and the residue is extracted into ether, washed with water, saturated sodium chloride solution, dried and evaporated to dryness to obtain α-mercapto-6-methoxy-2-naphthylacetic acid.

Workup

  1. customThe solvent is removed in vacuo
  2. extractionthe residue is extracted into ether
  3. washwashed with water, saturated sodium chloride solution
  4. customdried
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-ff1b5aaeb8d74a22ba56200738c657f6
Source dataset
uspto-grants-1976_01
Patent number
US03931269

Reaction notes

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