反应详情

A solution of 10.8 g. (0.05 mole) of 2-phenacylcyclohexanone, 7.55 g. (0.05 mole) of methyl anthranilate, and 30 ml. of glacial acetic acid was heated under reflux for 7 hours, cooled, and diluted with water. The layers were separated, and the aqueous phase was extracted with ether. The combined organic phase was washed with sodium bicarbonate solution, dried over sodium sulfate, and concentrated to an oil. Chromatography on silica gel with toluene as the eluent gave 2.91 g. (18%) of a yellow oil.

1. temperatureunder reflux for 7 hours
2. temperaturecooled
3. customThe layers were separated
4. extractionthe aqueous phase was extracted with ether
5. washThe combined organic phase was washed with sodium bicarbonate solution
6. dry with materialdried over sodium sulfate
7. concentrationconcentrated to an oil
8. customChromatography on silica gel with toluene as the eluent gave 2.91 g