Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 1-(2-Methoxycarbonylphenyl)-2-phenyl-4,5,6,7-tetrahydroindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Methyl Anthranilate | HCID 8635 | — |
| 반응물 | 2-(2-Oxo-2-phenylethyl)cyclohexanone | HCID 10512899 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(2-Methoxycarbonylphenyl)-2-phenyl-4,5,6,7-tetrahydroindole | HCID 21569622 | — |
반응 단계
A solution of 10.8 g. (0.05 mole) of 2-phenacylcyclohexanone, 7.55 g. (0.05 mole) of methyl anthranilate, and 30 ml. of glacial acetic acid was heated under reflux for 7 hours, cooled, and diluted with water. The layers were separated, and the aqueous phase was extracted with ether. The combined organic phase was washed with sodium bicarbonate solution, dried over sodium sulfate, and concentrated to an oil. Chromatography on silica gel with toluene as the eluent gave 2.91 g. (18%) of a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03931407 |
| 출처 데이터셋 | uspto-grants-1976_01 |
| ORD ID | ord-5b7885ef39ff4343a380fc5e107c5f6e |
| 출처 메모 | uspto-grants-1976_01 |