HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminobenzoic Acid → 4-(2-phenyl-4,5,6,7-tetrahydro-1H-indol-1-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminobenzoic Acid | HCID 978 | — |
| Reactant | 2-(2-Oxo-2-phenylethyl)cyclohexanone | HCID 10512899 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-(2-phenyl-4,5,6,7-tetrahydro-1H-indol-1-yl)benzoic acid | HCID 6623370 | — |
Reaction Steps
A solution of 10.8 g. (0.05 mole) of 2-phenacylcyclohexanone, 6.85 g. (0.05 mole) of p-aminobenzoic acid and 30 ml. of glacial acetic acid was heated under reflux for 5 hours and cooled. The solid which separated was collected and recrystallized from ethanol to provide 5.85 g. (37%) of pale yellow crystals, m.p. 244°-246°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931407 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-89efef959bb24191b0390427ec7072a7 |
| Source note | uspto-grants-1976_01 |