反应详情

A solution of 32.4 g. (0.15 mole) of 2-phenacylcyclohexanone, 23.0 g. (0.15 mole) of 4-aminosalicylic acid and 90 ml. of glacial acetic acid was heated under reflux for 7 hours, cooled, diluted with 90 ml. of water and extracted with ether. The ether solution was dried over sodium sulfate and concentrated. The residue was recrystallized from benzene-ethanol to provide 3.36 g. (7%) of yellow crystals, m.p. 193°-195°.

1. temperatureunder reflux for 7 hours
2. temperaturecooled
3. additiondiluted with 90 ml
4. extractionof water and extracted with ether
5. dry with materialThe ether solution was dried over sodium sulfate
6. concentrationconcentrated
7. customThe residue was recrystallized from benzene-ethanol
8. customto provide 3.36 g