5-Aminosalicylic Acid → HCID 9967439, compound

HRID 1579864Notes

Reaction equation

HRID 1579864 reaction equation
[CH2:1]([CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C:11]1=O)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=O.[NH2:17][C:18]1[CH:26]=[C:22]([C:23]([OH:25])=[O:24])[C:21]([OH:27])=[CH:20][CH:19]=1>C(O)(=O)C>[C:23]([C:22]1[CH:26]=[C:18]([N:17]2[C:11]3[CH2:12][CH2:13][CH2:14][CH2:15][C:10]=3[CH:1]=[C:2]2[C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:19]=[CH:20][C:21]=1[OH:27])([OH:25])=[O:24]

Participants

4

Reactant 2

HCID 40755-Aminosalicylic AcidHCID 105128992-(2-Oxo-2-phenylethyl)cyclohexanone

Product 1

HCID 9967439HCID 9967439, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 49.7 g. (0.23 mole) of 2-phenacylcyclohexanone, 35.2 g. (0.23 mole) of 5-aminosalicylic acid, and 135 ml. of glacial acetic acid was heated under reflux under nitrogen for 31/2 hours. A solid separated and was collected, washed with water, and recrystallized from acetic acid to provide 46.0 g. (60%) of pale yellow crystals, m.p. 209°-211°.

Workup

  1. temperatureunder reflux under nitrogen for 31/2 hours
  2. customA solid separated
  3. customwas collected
  4. washwashed with water
  5. customrecrystallized from acetic acid
  6. customto provide 46.0 g

Sources & evidence

ORD record
ord-2ec61bad43804fb39d6dbb66d027f5b9
Source dataset
uspto-grants-1976_01
Patent number
US03931407

Reaction notes

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