反应详情

Hydrogen chloride gas was bubbled through a boiling mixture of 25.0 g. (0.075 mole) of 1-(3-carboxy-4-hydroxyphenyl) 2-phenyl-4,5,6,7-tetrahydroindole and 750 ml. of methanol for 2 hours. The mixture was heated under reflux for 18.5 hours, cooled and filtered to provide 19.6 g. (75%) of white solid. Recrystallization from methanol gave colorless crystals, m.p. 141°-142°.

1. customHydrogen chloride gas was bubbled through a boiling mixture of 25.0 g
2. temperatureThe mixture was heated
3. temperatureunder reflux for 18.5 hours
4. temperaturecooled
5. filtrationfiltered
6. customto provide 19.6 g
7. customRecrystallization from methanol
8. customgave colorless crystals, m.p. 141°-142°