Methanol → 1-(4-Hydroxy-3-methoxycarbonylphenyl)-2-phenyl-4,5,6,7-tetrahydroindole

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Reaction Steps

Hydrogen chloride gas was bubbled through a boiling mixture of 25.0 g. (0.075 mole) of 1-(3-carboxy-4-hydroxyphenyl) 2-phenyl-4,5,6,7-tetrahydroindole and 750 ml. of methanol for 2 hours. The mixture was heated under reflux for 18.5 hours, cooled and filtered to provide 19.6 g. (75%) of white solid. Recrystallization from methanol gave colorless crystals, m.p. 141°-142°.

Provenance & Evidence