反应详情

A mixture of 3.33 g. (0.01 mole) of 1-(3-carboxy-4-hydroxyphenyl)-2-phenyl-4,5,6,7-tetrahydroindole, 4.0 g. of 10% palladium on carbon, and 250 ml. of xylene was heated under reflux with stirring under nitrogen for 3 days, filtered, and concentrated to a solid. Trituration with cyclohexane afforded 2.4 g. (73%) of solid, m.p. 210°-212°. Recrystallization from acetic acid gave colorless crystals, m.p. 213.5°-214.5°.

1. additionA mixture of 3.33 g
2. temperatureunder reflux
3. filtrationfiltered
4. concentrationconcentrated to a solid
5. customTrituration with cyclohexane afforded 2.4 g
6. customRecrystallization from acetic acid
7. customgave colorless crystals, m.p. 213.5°-214.5°