反应详情

A mixture of 8.25 g. (0.025 mole) of 1-(3-carboxy-4-hydroxyphenyl)-2-phenylindole and 76.5 g. (0.75 mole) of acetic anhydride was heated under reflux for 1 hour, diluted with 75 ml. of tetrahydrofuran and poured into 1 l. of water. An oil separated, and during 2 days solidified. The solid was collected and recrystallized from acetonitrile to provide 4.8 g. (52%) of colorless crystals, m.p. 178°-180°.

1. additionA mixture of 8.25 g
2. temperatureunder reflux for 1 hour
3. additiondiluted with 75 ml
4. customAn oil separated
5. customThe solid was collected
6. customrecrystallized from acetonitrile
7. customto provide 4.8 g