反应详情

A mixture of 12.0 g. (0.042 mole) of 2-(m-trifluoromethylphenacyl)cyclohexanone, 6.45 g. (0.042 mole) of 5-aminosalicylic acid, and 30 ml. of glacial acetic acid was heated under reflux for 4 hours and filtered. The filtrate was diluted with water and the supernatant was decanted from the oil which separated. Trituration with cyclohexane gave 7.7 g. of solid, m.p. 215°-225°. Recrystallization from isopropyl alcohol-water afforded 4.1 g. (47%) of crystals, m.p. 223°-225°.

1. additionA mixture of 12.0 g
2. temperatureunder reflux for 4 hours
3. filtrationfiltered
4. additionThe filtrate was diluted with water
5. customthe supernatant was decanted from the oil which
6. customseparated
7. customTrituration with cyclohexane gave 7.7 g
8. customRecrystallization from isopropyl alcohol-water
9. customafforded 4.1 g