HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminosalicylic Acid → HCID 12270298, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminosalicylic Acid | HCID 4075 | — |
| Reactant | Cyclohexanone, 2-[2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl]- | HCID 12270334 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 12270298 | HCID 12270298 | — |
Reaction Steps
A mixture of 12.0 g. (0.042 mole) of 2-(m-trifluoromethylphenacyl)cyclohexanone, 6.45 g. (0.042 mole) of 5-aminosalicylic acid, and 30 ml. of glacial acetic acid was heated under reflux for 4 hours and filtered. The filtrate was diluted with water and the supernatant was decanted from the oil which separated. Trituration with cyclohexane gave 7.7 g. of solid, m.p. 215°-225°. Recrystallization from isopropyl alcohol-water afforded 4.1 g. (47%) of crystals, m.p. 223°-225°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931407 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-42f41fc3bfba4ed69c96ec8d12ac8427 |
| Source note | uspto-grants-1976_01 |