反应详情

A solution of 20 g. (0.1 mole) of phenacyl bromide and 65 ml. of toluene was added during 30 minutes to a boiling, stirred solution of 20 g. (0.1 mole) of 1-(3,4-dihydro-2-naphthyl)pyrrolidine and 50 ml. of toluene. The mixture was heated under reflux for 3 hours, diluted with 50 ml. of water, refluxed for 4 hours and cooled. The layers were separated, the aqueous phase was extracted with benzene, and the organic solution was dried and concentrated to an oil. Crystallization from 30°-60°-petroleum ether-ether gave 16.7 g. (63%) of tan crystals, m.p. 48°-52°.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 3 hours
3. additiondiluted with 50 ml
4. temperaturecooled
5. customThe layers were separated
6. extractionthe aqueous phase was extracted with benzene
7. customthe organic solution was dried
8. concentrationconcentrated to an oil
9. customCrystallization from 30°-60°-petroleum ether-ether
10. customgave 16.7 g