HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminosalicylic Acid → Fendosal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminosalicylic Acid | HCID 4075 | — |
| Reactant | 1-(2-Oxo-2-phenyl-ethyl)-3,4-dihydro-1H-naphthalen-2-one | HCID 12270344 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Fendosal | HCID 40821 | — |
Reaction Steps
A mixture of 16.6 g. (0.063 mole) of 1-phenacyl-2-tetralone, 9.65 g. (0.063 mole) of 5-aminosalicylic acid, and 60 ml. of glacial acetic acid was heated under reflux under nitrogen for 2 hours, cooled and filtered. The collected solid was washed with acetic acid and water, dried and recrystallized from acetic acid to provide 16.3 g. (68%) of crystals, m.p. 223°-225°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931407 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-9124a46e6a85416ba27ab81c85da581e |
| Source note | uspto-grants-1976_01 |