Hydrochloric Acid → HCID 12270318, compound

HRID 1579880Notes

Reaction equation

HRID 1579880 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([N:11]2[C:19]3[CH2:18][CH2:17][C:16]4[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=4[C:14]=3[CH:13]=[C:12]2[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:7]=[CH:8][C:9]=1[OH:10])([OH:3])=[O:2].Cl.[CH2:31](O)[CH3:32]>>[CH2:31]([O:2][C:1]([C:4]1[CH:5]=[C:6]([N:11]2[C:19]3[CH2:18][CH2:17][C:16]4[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=4[C:14]=3[CH:13]=[C:12]2[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:7]=[CH:8][C:9]=1[OH:10])=[O:3])[CH3:32]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 40821Fendosal

Product 1

HCID 12270318HCID 12270318, compound

Procedure

A boiling solution of 7.5 g. (0.02 mole) of 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz[e]indole and 200 ml. of ethanol was saturated with hydrogen chloride, then heated under reflux for 26 hours and cooled. The solid which separated was collected and recrystallized from ethanol to provide 4.1 g. (51%) of off-white crystals, m.p. 134°-135°.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 26 hours
  3. temperaturecooled
  4. customThe solid which separated
  5. customwas collected
  6. customrecrystallized from ethanol
  7. customto provide 4.1 g

Sources & evidence

ORD record
ord-1c17e5e01a924dd7b32a52417076795e
Source dataset
uspto-grants-1976_01
Patent number
US03931407

Reaction notes

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