反应详情

A mixture of 1.25 g. (0.0033 mole) of 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz[e]indole, 1 ml. of acetic anhydride, 10 ml. of glacial acetic acid, and 0.1 g. of p-toluenesulfonic acid was stirred at room termperature under nitrogen for 6 days. The solid which separated was collected, washed with acetic acid and petroleum ether, dried and recrystallized from methanol to provide 0.23 g (16%) of 3-(4-acetoxy-3-carboxyphenyl)-1-acetyl-4,5-dihydro-2-phenylbenz[e]indole. Concentration of the mother liquor, followed by recrystallization of the residue from ethanol-water, gave 0.25 g. (18%) of crystals, m.p. 223°-226°.

1. additionA mixture of 1.25 g
2. customThe solid which separated
3. customwas collected
4. washwashed with acetic acid and petroleum ether
5. customdried
6. customrecrystallized from methanol