Acetic Anhydride → 3-(4-Acetoxy-3-carboxyphenyl)-4,5-dihydro-2-phenylbenz[e]indole

Participants

Reaction Steps

A mixture of 26.2 g. (0.069 mole) of 3-(3-carboxy-4-hydroxyphenyl)-4,5-dihydro-2-phenylbenz[e]indole and 204 g. of acetic anhydride was stirred at 75° for 4 hours, cooled, treated with 34 g. of water, stirred for several hours until a solution formed, and allowed to stand overnight. The solid which separated was collected, washed with acetic acid and petroleum ether, and dried to provide 26.7 g. (91%) of crystals, m.p. 194°-196°.

Provenance & Evidence