2-(2-Oxo-2-phenylethyl)cyclohexanone → HCID 12270285, compound

HRID 1579885Notes

Reaction equation

HRID 1579885 reaction equation
[NH2:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][C:3]=1[C:12]([F:15])([F:14])[F:13].[CH2:16]([CH:25]1[CH2:30][CH2:29][CH2:28][CH2:27][C:26]1=O)[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=O>C(O)(=O)C>[C:19]1([C:17]2[N:1]([C:2]3[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][C:3]=3[C:12]([F:13])([F:14])[F:15])[C:26]3[CH2:27][CH2:28][CH2:29][CH2:30][C:25]=3[CH:16]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 105128992-(2-Oxo-2-phenylethyl)cyclohexanoneHCID 21569608HCID 21569608, compound

Product 1

HCID 12270285HCID 12270285, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 6.5 g. (0.029 mole) of 5-amino-4-trifluoromethylsalicylic acid, 6.35 g. (0.029 mole) of 2-phenacylcyclohexanone, and 30 ml. of glacial acetic acid was heated under reflux for 3 hours, cooled and filtered. The filter cake was recrystallized from acetic acid to provide 4.6 g. (39%) of gold crystals, m.p. 188°-190°.

Workup

  1. additionA mixture of 6.5 g
  2. temperatureunder reflux for 3 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. customThe filter cake was recrystallized from acetic acid
  6. customto provide 4.6 g

Sources & evidence

ORD record
ord-7925a4da242b41b5af123b67a658b254
Source dataset
uspto-grants-1976_01
Patent number
US03931407

Reaction notes

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