反应详情

a solution of 50 g. (0.22 mole) of 4-methyl-2-phenacylcyclohexanone, 33.7 g. (0.22 mole) of 5-aminosalicylic acid, and 257 ml. of glacial acetic acid was heated under reflux for 3 hours, cooled and filtered. The collected solid was washed with water and recrystallized from acetonitrile to provide 43.3 g. (57%) of yellow crystals, m.p. 213°-215°.

1. temperatureunder reflux for 3 hours
2. temperaturecooled
3. filtrationfiltered
4. washThe collected solid was washed with water
5. customrecrystallized from acetonitrile
6. customto provide 43.3 g