HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminosalicylic Acid → 1-(3-Carboxy-4-hydroxyphenyl)-5-methyl-2-phenyl-4,5,6,7-tetrahydroindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminosalicylic Acid | HCID 4075 | — |
| Reactant | 4-Methyl-2-(2-oxo-2-phenylethyl)cyclohexanone | HCID 12270340 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-(3-Carboxy-4-hydroxyphenyl)-5-methyl-2-phenyl-4,5,6,7-tetrahydroindole | HCID 12270310 | — |
Reaction Steps
a solution of 50 g. (0.22 mole) of 4-methyl-2-phenacylcyclohexanone, 33.7 g. (0.22 mole) of 5-aminosalicylic acid, and 257 ml. of glacial acetic acid was heated under reflux for 3 hours, cooled and filtered. The collected solid was washed with water and recrystallized from acetonitrile to provide 43.3 g. (57%) of yellow crystals, m.p. 213°-215°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931407 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-fb23a48c86634586b2e838f2c2738133 |
| Source note | uspto-grants-1976_01 |