2-(2-Oxo-2-phenylethyl)cyclohexanone → HCID 12270288, compound

HRID 1579896Notes

Reaction equation

HRID 1579896 reaction equation
[CH2:1]([CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][C:11]1=O)[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=O.[C:17]([NH:20][C:21]1[CH:29]=[C:28]([NH2:30])[CH:27]=[C:23]([C:24]([OH:26])=[O:25])[C:22]=1[OH:31])(=[O:19])[CH3:18]>C(O)(=O)C>[C:17]([NH:20][C:21]1[C:22]([OH:31])=[C:23]([C:24]([OH:26])=[O:25])[CH:27]=[C:28]([N:30]2[C:11]3[CH2:12][CH2:13][CH2:14][CH2:15][C:10]=3[CH:1]=[C:2]2[C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:29]=1)(=[O:19])[CH3:18]

Participants

4

Reactant 2

HCID 105128992-(2-Oxo-2-phenylethyl)cyclohexanoneHCID 12270347HCID 12270347, compound

Product 1

HCID 12270288HCID 12270288, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 10.3 g. (0.048 mole) of 2-phenacylcyclohexanone, 10 g. (0.048 mole) of 3-acetamido-5-aminosalicylic acid, and 70 ml. of glacial acetic acid was heated under reflux under nitrogen for 1 hour, cooled and filtered. Recrystallization of the collected solid from acetic acid gave 10.5 g. (57%) of crystals, m.p. 232°-234°.

Workup

  1. additionA mixture of 10.3 g
  2. temperatureunder reflux under nitrogen for 1 hour
  3. temperaturecooled
  4. filtrationfiltered
  5. customRecrystallization of the collected solid from acetic acid
  6. customgave 10.5 g

Sources & evidence

ORD record
ord-8da86c221c1f4a44830b44b43f570202
Source dataset
uspto-grants-1976_01
Patent number
US03931407

Reaction notes

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