Ethyl Acetate → HCID 21564497, compound

HRID 1579954Notes

Reaction equation

HRID 1579954 reaction equation
[CH2:1]([O:8][C:9]1[CH:31]=[CH:30][C:12]2[CH2:13][CH2:14][C:15]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[C:16]=3[CH2:17][N:18]([CH3:21])[CH2:19][CH2:20][C:11]=2[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OCC)(=[O:34])C>N1C=CC=CC=1.[O-2].[O-2].[O-2].[Cr+6]>[CH2:1]([O:8][C:9]1[CH:31]=[CH:30][C:12]2[CH2:13][CH2:14][C:15]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([O:28][CH3:29])[C:16]=3[CH2:17][N:18]([CH:21]=[O:34])[CH2:19][CH2:20][C:11]=2[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 8857Ethyl AcetateHCID 21564452HCID 21564452, compound

Product 1

HCID 21564497HCID 21564497, compound

Reagents, catalysts & solvents 2

HCID 10219390chromium (VI) trioxideCatalystHCID 1049PyridineSolvent2×

Procedure

To a chromium trioxide - pyridine complex freshly prepared from 28 g of chromium trioxide and 280 ml of anhydrous pyridine is added dropwise a solution of 21 g of 10-benzyloxy-3,4-dimethoxy-6-methyl-5,6,7,8,13,14-hexahydrodibenz[c,g]azecine in 140 ml of pyridine at 10° - 15°C over a period of 35 minutes, and the mixture is allowed to stand at the same temperature for 2 hours and then at room temperature for 15 hours. The mixture is then diluted with 600 ml of ethyl acetate, stirred well, and filtered to remove the inorganic precipitate. The filtrate is passed through a column of alumina and celite (kiesel-guhr) and evaporated to dryness. The resulting residue (14.3 g) is dissolved in 286 ml of methanol, treated with 7 g of sodium borohydride, and chromatographed on 140 g of silica gel. The benzene - ethyl acetate (10 : 1) elution (2.45 g) is recrystallized from methylene chloride - ether to yield 2.11 g of 10-benzyloxy-3,4-dimethoxy-6-formyl-5,6,7,8,13,14-hexahydrodibenz[c,g]azecine as colorless needles having mp. 140° - 141°C. IR: νmaxCHCl 3 1654 cm-1. Anal. Calcd. for C27H29O4N: C, 75.15%; H, 6.77%; N, 3.25%. Found: C, 75.20%; H, 7.02%; N, 3.23%.

Workup

  1. waitat room temperature for 15 hours
  2. filtrationfiltered
  3. customto remove the inorganic precipitate
  4. customevaporated to dryness
  5. dissolutionThe resulting residue (14.3 g) is dissolved in 286 ml of methanol
  6. additiontreated with 7 g of sodium borohydride
  7. customchromatographed on 140 g of silica gel
  8. washThe benzene - ethyl acetate (10 : 1) elution (2.45 g)
  9. customis recrystallized from methylene chloride - ether

Sources & evidence

ORD record
ord-a76e6b8a6e134ec09c8f9421e533500b
Source dataset
uspto-grants-1976_01
Patent number
US03932384

Reaction notes

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