Cephalosporin C → Dicyclohexylamine

Participants

Reaction Steps

Concentration in vacuo or at atmospheric pressure of the mother liquors leaves a post residue consisting of essentially dicyclohexylamine hydrochloride, water and unreacted or decomposed cephalosporin C by-products. Basification of the pH to about 9 with sodium hydroxide, followed by physical separation of the two layers produces essentially pure dicyclohexylamine in about 85-95% recofery of theory.

Provenance & Evidence