反应详情

About 40 g of 5-methyl-2-phenylimidazole-4-acetic acid, 100 ml of absolute ethanol, 1 g of p-toluenesulfonic acid and 650 ml of benzene is heated under reflux with azeotropic removal of water overnight (about 15 hours). The reaction mixture is filtered, washed with sodium bicarbonate solution, dried over anhydrous magnesium sulfate and the solvent evaporated in vacuo to yield the product, ethyl 5-methyl-2-phenylimidazole-4-acetate.

1. filtrationThe reaction mixture is filtered
2. washwashed with sodium bicarbonate solution
3. dry with materialdried over anhydrous magnesium sulfate
4. customthe solvent evaporated in vacuo