HCID 131709904, compound → HCID 131709903, compound

HRID 1580174Notes

Reaction equation

HRID 1580174 reaction equation
[CH3:1][C:2]1([CH3:33])[CH:29]2[C:24]([CH2:25][N:26]([CH2:30][C:31]#[CH:32])[CH2:27][CH2:28]2)=[C:5]2[C:6]([OH:23])([OH:22])[CH:7]=[C:8]([CH:10]([CH3:21])[CH2:11][CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[CH:9]=[C:4]2[O:3]1.[H][H]>C(O)C>[CH3:33][C:2]1([CH3:1])[CH:29]2[C:24]([CH2:25][N:26]([CH2:30][CH2:31][CH3:32])[CH2:27][CH2:28]2)=[C:5]2[C:6]([OH:23])([OH:22])[CH:7]=[C:8]([CH:10]([CH3:21])[CH2:11][CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[CH:9]=[C:4]2[O:3]1

Participants

4

Reactant 2

HCID 131709904HCID 131709904, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 131709903HCID 131709903, compound

Reagents, catalysts & solvents 1

HCID 702EthanolCatalyst

Procedure

5,5-Dimethyl-8-(4-p-fluorophenyl-1-methylbutyl)-2-(2-propynyl)-10-hydroxy-1,2,3,4-tetrahydro-5H[1]benzopyrano [4,3-c]pyridin-10-ol was hydrogenated in ethanol using 5% palladium on carbon as a catalyst. When two equivalents of hydrogen were taken up, the catalyst was filtered and solution concentrated to give the desired product.

Workup

  1. filtrationthe catalyst was filtered
  2. concentrationsolution concentrated

Sources & evidence

ORD record
ord-80ab27823adf47018c2c865f571fc954
Source dataset
uspto-grants-1976_01
Patent number
US03932432

Reaction notes

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