Ethanol → HCID 85441254, compound

HRID 1580190Notes

Reaction equation

HRID 1580190 reaction equation
Cl.[NH2:2][OH:3].[Br:4][CH2:5][C:6](=O)[C:7]([CH3:10])([CH3:9])[CH3:8].C(O)C>O>[Br:4][CH2:5][C:6](=[N:2][OH:3])[C:7]([CH3:10])([CH3:9])[CH3:8]

Participants

5

Reactant 3

HCID 702EthanolHCID 21642BromopinacoloneHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 85441254HCID 85441254, compoundYield 56.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 69.5 g (1.0 m) of hydroxylamine hydrochloride in 100 ml of water is chilled in an ice bath as 90 g (0.5 m) of 1-bromo-3,3-dimethyl-2-butanone is added. After addition of 100 ml of 95% ethanol, the mixture is stirred for 16 hours and allowed to warm to room temperature. The resulting white slurry is filtered, and the solid is washed with water and dried to give 55 g of the desired compound, m. 111°-112° C.

Workup

  1. additionis added
  2. filtrationThe resulting white slurry is filtered
  3. washthe solid is washed with water
  4. customdried

Sources & evidence

ORD record
ord-e4f7c782d5f642a59a29670aab6ef1ef
Source dataset
uspto-grants-1976_01
Patent number
US03932471

Reaction notes

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