Hydrofluoric Acid → HCID 12251281, compound

HRID 1580255Notes

Reaction equation

HRID 1580255 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][CH:3]1CCC(O)=O.F>>[C:5]12([CH2:4][CH2:3][C:2](=[O:1])[CH2:7][CH2:6]1)[C:8]1[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2](=[O:1])[CH2:3][CH2:4]2

Participants

3

Reactant 2

HCID 14917Hydrofluoric AcidHCID 21433513HCID 21433513, compound

Product 1

HCID 12251281HCID 12251281, compound

Procedure

A 4-oxo-1-phenylcyclohexane-3-propionic acid (i) prepared in step (6) or (6') is cyclized, e.g., by allowing it to stand at room temperature for from about 15 to about 80 hours with liquid hydrogen fluoride, to yield a corresponding spiro[cyclohexane-1,1'(2'H)-naphthalene]-4,4'(3'H)-dione (o).

Sources & evidence

ORD record
ord-eacd3e6c75c2454fb092f9f7f0c5af28
Source dataset
uspto-grants-1976_01
Patent number
US03932425

Reaction notes

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