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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1580300Generated: October 27, 2026

2-Chloroethanol → o-(beta-Hydroxyethoxy)-thioanisole

https://huagongshe.com/reaction/1580300

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-ChloroethanolHCID 34—
Reactanto-(Methylthio)phenolHCID 61261—
ReactantSodium ethoxideHCID 2723922—
SolventEthanolHCID 702—
Producto-(beta-Hydroxyethoxy)-thioanisoleHCID 22036270—

Reaction Steps

o-Hydroxythioanisole (14.1 g., 0.1 mole) is dissolved in sodium ethoxide (6.8 g., 0.1 mole) in absolute ethanol (100 ml.) and stirred as β-hydroxyethyl chloride (8.1 g., 0.1 mole) is added. The reaction mixture is refluxed for 2 hours and cooled. The o-(β-hydroxyethoxy)-thioanisole is extracted.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS03932498
Source datasetuspto-grants-1976_01
ORD IDord-5316a52c36a048fdaa525ded247bf4f2
Source noteuspto-grants-1976_01