Urea → HCID 63996103, compound

HRID 1580325Notes

Reaction equation

HRID 1580325 reaction equation
[NH2:1][C:2]([NH2:4])=[O:3].[CH3:5][CH:6]1[CH2:11][CH:10]([CH3:12])[CH2:9][CH2:8][CH:7]1N.C([O-])(=O)C>O1CCOCC1>[CH3:5][CH:6]1[CH2:11][CH:10]([CH3:12])[CH2:9][CH2:8][CH:7]1[NH:1][C:2](=[O:3])[NH2:4]

Participants

4

Reactant 2

HCID 1176UreaHCID 131709910HCID 131709910, compound

Product 1

HCID 63996103HCID 63996103, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

8.2 g of N-[4-(β-<2-methoxy-5-chloro-benzamido>-ethyl)-benzenesulfonyl]-urea.(melting point 171°-173°C) are suspended in 150 ml of dioxane and heated under reflux for 1 hour after addition of 3.75 g of 2.4-dimethyl-cyclohexyl-amine-acetate. Then the solvent is distilled off in vacuo and water is added to the residue. The crystals obtained of N-[4-(β-<2-methoxy5-chlorobenzamido>-ethyl)-benzenesulfonyl]-N'-(2.4-dimethylcyclohexyl)-urea are recrystallized from methanol/dimethyl formamide and melt at 200°-201°C.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 1 hour
  3. distillationThen the solvent is distilled off in vacuo and water
  4. additionis added to the residue

Sources & evidence

ORD record
ord-41fbfdaebcd24f0aae8c9245fedd6b06
Source dataset
uspto-grants-1976_01
Patent number
US03932503

Reaction notes

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