反应详情

A mixture of 6 g. of 2-(6-carbethoxyhexyl)-2-cyclopentenone, 10 ml. of propanethiol, and 7.2 ml. of piperidine is allowed to stand for 5 days at room temperature, then diluted with 150 ml. of ether, and the ether phase is washed first with a mixture of 60 ml. of ice water and 6 ml. of concentrated HCl, and then with saturated aqueous NaCl solution, dried over NaSO4, and the solvent distilled off. After purifying the residue by chromatography (silica gel/chloroform), 2-(carbethoxyhexyl)-3-propylthio-cyclopentanone is produced as an oil.

1. additionA mixture of 6 g
2. additiondiluted with 150 ml
3. washof ether, and the ether phase is washed first with a mixture of 60 ml
4. dry with materialof concentrated HCl, and then with saturated aqueous NaCl solution, dried over NaSO4
5. distillationthe solvent distilled off
6. customAfter purifying the residue by chromatography (silica gel/chloroform)