反应详情

At room temperature, 70 ml. of a 0.2N diazoethane solution in ether is added to a solution of 3.4 g. of 2-(6-carboxyhexyl)-3-heptylthio-cyclopentanone in 25 ml. of dry ethanol. The reaction mixture is poured into 100 ml. of ice water, containing 5 ml. of concentrated HCl, agitated, the organic phase separated, the aqueous phase extracted three times with respectively 30 ml. of chloroform, and the combined organic phases are washed with water, dried over Na2SO4, the solvent is distilled off, and chromatographic purification of the residue (silica gel/chloroform) produces 2-(6-carbethoxyhexyl)-3-heptylthio-cyclopentanone. Rf = 0.7 (silica gel/chloroform).

1. customAt room temperature
2. additionThe reaction mixture is poured into 100 ml
3. customthe organic phase separated
4. extractionthe aqueous phase extracted three times with respectively 30 ml
5. washof chloroform, and the combined organic phases are washed with water
6. dry with materialdried over Na2SO4
7. distillationthe solvent is distilled off
8. customchromatographic purification of the residue (silica gel/chloroform)