Acetone → HCID 178503577, compound

HRID 1580434Notes

Reaction equation

HRID 1580434 reaction equation
[C:1]1([N:7]2[C:11]([SH:12])=[N:10]C=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:13]C(C)=O.CI.[C:19](=[O:22])([O-])[O-].[Na+].[Na+]>O>[C:1]1([N:7]2[C:11]([S:12][CH3:13])=[N:10][C:19]([OH:22])=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 180AcetoneHCID 6328Methyl iodideHCID 10340Sodium CarbonateHCID 178527895HCID 178527895, compound

Product 1

HCID 178503577HCID 178503577, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

An amount of 23.2 g of 1-phenyl-5-mercapto-1,2,4-triazole, M.P. 220°C, is placed into 50 ml of acetone, 50 ml of water and 10 ml of methyliodide. An addition is then made in portions, within 15 minutes, of 21 g of sodium carbonate, and, after completion of the addition, stirring continued for 1 hour at 30°C. The acetone is evaporated off, and the solution acidified with dilute hydrochloric acid. The precipitated product is filtered off, and recrystallised from 250 ml of ethanol to obtain 1-phenyl-5-methylmercapto-3-hydroxy-1,2,4-triazole in the form of white crystals having a melting point of 176°-177°C.

Workup

  1. additionAn addition
  2. additionafter completion of the addition
  3. customThe acetone is evaporated off
  4. filtrationThe precipitated product is filtered off
  5. customrecrystallised from 250 ml of ethanol

Sources & evidence

ORD record
ord-6c835d7373054f198aa5403ec4c4cc4c
Source dataset
uspto-grants-1976_01
Patent number
US03932630

Reaction notes

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