Acetone → HCID 178503577, compound

Participants

Reaction Steps

An amount of 23.2 g of 1-phenyl-5-mercapto-1,2,4-triazole, M.P. 220°C, is placed into 50 ml of acetone, 50 ml of water and 10 ml of methyliodide. An addition is then made in portions, within 15 minutes, of 21 g of sodium carbonate, and, after completion of the addition, stirring continued for 1 hour at 30°C. The acetone is evaporated off, and the solution acidified with dilute hydrochloric acid. The precipitated product is filtered off, and recrystallised from 250 ml of ethanol to obtain 1-phenyl-5-methylmercapto-3-hydroxy-1,2,4-triazole in the form of white crystals having a melting point of 176°-177°C.

Provenance & Evidence