Potassium Fluoride → HCID 178456692, compound

Participants

Reaction Steps

16.2 g of 1-isopropyl-5-chloro-3-hydroxy-1,2,4-triazole, 29 g of dry potassium fluoride and 150 ml of sulpholane are heated together for 16 hours to 160°-200°C. The solvent is evaporated in a high vacuum and the residue then treated with 10 % acetic acid and extracted with ethyl acetate. The ethyl acetate is evaporated off and the residueal solid is recrystallised from water, in the process of which 1-isopropyl-5-fluoro-3-hydroxy-1,2,4-triazole is obtained in the form of white crystals with a melting point of 80°-95°C. The product can be recrystallised from an organic solvent in order to purify it further.

Provenance & Evidence