Potassium Fluoride → HCID 178456692, compound

HRID 1580441Notes

Reaction equation

HRID 1580441 reaction equation
[CH:1]([N:4]1[C:8](Cl)=[N:7][C:6]([OH:10])=[N:5]1)([CH3:3])[CH3:2].[F-:11].[K+]>S1(CCCC1)(=O)=O>[CH:1]([N:4]1[C:8]([F:11])=[N:7][C:6]([OH:10])=[N:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 522689Potassium FluorideHCID 178456690HCID 178456690, compound

Product 1

HCID 178456692HCID 178456692, compound

Reagents, catalysts & solvents 1

HCID 31347SulfolaneSolvent

Procedure

16.2 g of 1-isopropyl-5-chloro-3-hydroxy-1,2,4-triazole, 29 g of dry potassium fluoride and 150 ml of sulpholane are heated together for 16 hours to 160°-200°C. The solvent is evaporated in a high vacuum and the residue then treated with 10 % acetic acid and extracted with ethyl acetate. The ethyl acetate is evaporated off and the residueal solid is recrystallised from water, in the process of which 1-isopropyl-5-fluoro-3-hydroxy-1,2,4-triazole is obtained in the form of white crystals with a melting point of 80°-95°C. The product can be recrystallised from an organic solvent in order to purify it further.

Workup

  1. customThe solvent is evaporated in a high vacuum
  2. additionthe residue then treated with 10 % acetic acid
  3. extractionextracted with ethyl acetate
  4. customThe ethyl acetate is evaporated off
  5. customthe residueal solid is recrystallised from water, in the process of which 1-isopropyl-5-fluoro-3-hydroxy-1,2,4-triazole
  6. customis obtained in the form of white crystals with a melting point of 80°-95°C
  7. customThe product can be recrystallised from an organic solvent in order
  8. customto purify it further

Sources & evidence

ORD record
ord-cd673947d4b740c198cdf22a8fe14316
Source dataset
uspto-grants-1976_01
Patent number
US03932629

Reaction notes

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