反应详情

To a solution of 22.2 g. of methyl magnesium chloride in ether is added 10.5 g. of 4-pyrimidinecarbonitrile in tetrahydrofuran. The resulting mixture is heated at reflux for 24 hours, then poured onto ice. To the mixture is added 75 ml. of 25% sulfuric acid. The solution is then made basic with 10% aqueous sodium carbonate solution and extracted with ether. The extracts are dried and concentrated to give methyl 4-pyrimidyl ketone.

1. temperatureThe resulting mixture is heated
2. temperatureat reflux for 24 hours
3. additionpoured onto ice
4. additionTo the mixture is added 75 ml
5. extractionextracted with ether
6. customThe extracts are dried
7. concentrationconcentrated