Toluene → HCID 131709928, compound

HRID 1580494Notes

Reaction equation

HRID 1580494 reaction equation
C(O[CH2:5][C:6]1[CH:11]([C:12]([OH:14])=[O:13])[N:10]2[C:15](=[O:26])[C@@H:16]([C:17](=[O:25])[CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C@H:9]2[S:8][C:7]=1[NH2:27])(=O)C.[C:28]1(C)C=C[CH:31]=[CH:30][CH:29]=1.FC(F)(F)C(O)=[O:38]>>[CH2:5]([C:6]1[CH:11]([C:12]([OH:14])=[O:13])[N:10]2[C:15](=[O:26])[C@@H:16]([C:17](=[O:25])[CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C@H:9]2[S:8][C:7]=1[NH2:27])[C:28]1[O:38][CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 1140TolueneHCID 6422Trifluoroacetic acidHCID 131709927HCID 131709927, compound

Product 1

HCID 131709928HCID 131709928, compound

Procedure

A solution of 7.8 g of 3-acetyloxymethyl-7β-phenylacetyl-amino-ceph-2-em-4ξ-carboxylic acid in 60 ml of trifluoroacetic acid, prepared at room temperature within 15 minutes, is treated with an equal volume of toluene and evaporated to dryness. The residue, which contains the 7β-phenylacetyl-amino-3-trifluoroacetyloxymethyl-ceph-2-em-4ξ-carboxylic acid, is dissolved in 200 ml of dry formamide and treated with 5.80 ml of furan. After reacting for 1 hour at 50° under nitrogen, the reaction mixture is cooled and treated with ethyl acetate and 10% aqueous dipotassium hydrogen phosphate solution (pH 7.5). The aqueous solution is separated and washed several times with ethyl acetate. The aqueous phase is adjusted to pH 2.5 with 20% aqueous phosphoric acid and extracted with ethyl acetate. The resulting organic extract is washed with water and a saturated aqueous sodium chloride solution, dried over magnesium sulphate and evaporated under reduced pressure. The solid residue is crystallised from ethal acetate to yield the almost pure 3-furfuryl-7β-phenylacetyl-amino-ceph- 2-em-4ξ-carboxylic acid, which after repeated recrystallisation from ethyl acetate melts at 188°-190°: thin-layer chromatogram (silica gel): Rf = 0.75 (system n-butanol/acetic acid/water 67:10: 23) and Rf = 0.53 (system n-butanol/ethanol/water 40:10:50); ultraviolet absorption spectrum (in methanol): strong terminal absorption; infrared absorption spectrum (in mineral oil); characteristic bands at 3,01μ, 5,66μ, 5,75μ, 6,02μ and 6,54μ.

Workup

  1. customevaporated to dryness
  2. dissolutionis dissolved in 200 ml of dry formamide
  3. additiontreated with 5.80 ml of furan
  4. temperaturethe reaction mixture is cooled
  5. additiontreated with ethyl acetate and 10% aqueous dipotassium hydrogen phosphate solution (pH 7.5)
  6. customThe aqueous solution is separated
  7. washwashed several times with ethyl acetate
  8. extractionextracted with ethyl acetate
  9. extractionThe resulting organic extract
  10. washis washed with water
  11. dry with materiala saturated aqueous sodium chloride solution, dried over magnesium sulphate
  12. customevaporated under reduced pressure
  13. customThe solid residue is crystallised from ethal acetate

Sources & evidence

ORD record
ord-5e5e6ca5ff16426d8b92a4b164a7ea12
Source dataset
uspto-grants-1976_01
Patent number
US03932465

Reaction notes

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