HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → 3'-Chloro-4'-(N-methylcarbamoyloxy)-5'-nitroacetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 1-(3-Chloro-4-hydroxy-5-nitrophenyl)-ethanone | HCID 21561878 | — |
| Product | 3'-Chloro-4'-(N-methylcarbamoyloxy)-5'-nitroacetophenone | HCID 21561896 | — |
Reaction Steps
A mixture of 21.5 grams (0.1 mole) 3'-chloro-4'-hydroxy-5'-nitroacetophenone and 85.0 milliliters (a large excess) of methylisocyanate was refluxed for 5 hours. On cooling, a white crystalline product was formed. The product was filtered (weight 18.0 grams, melting point 115°-118° C.) and was identified by characteristic peaks in the infrared spectrum as 3'-chloro-4'-(N-methylcarbamoyloxy)-5'-nitroacetophenone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03933472 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-2d1d34664ce748c9befeff1e2ea8202e |
| Source note | uspto-grants-1976_01 |