Dipropylamine → HCID 178457187, compound

HRID 1580552Notes

Reaction equation

HRID 1580552 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[N:6]=[C:7]([CH2:17]Cl)[NH:8][SH:9](=[O:16])([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:4]=2[CH:3]=1.[CH2:21]([NH:24][CH2:25][CH2:26][CH3:27])[CH2:22][CH3:23]>CO>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[N:6]=[C:7]([CH2:17][N:24]([CH2:25][CH2:26][CH3:27])[CH2:21][CH2:22][CH3:23])[NH:8][SH:9](=[O:16])([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 8902DipropylamineHCID 178527222HCID 178527222, compound

Product 1

HCID 178457187HCID 178457187, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5g 7-chloro-3-chloromethyl-1-phenyl-benzo-1,2,4-thiadiazine-1-oxide and 20 g di-n-propylamine are dissolved in 80 ml methanol and left standing for 12 hours at room temperature. Thereafter the solution is evaporated and the residue distributed between chloroform and water. The chloroform phase is extracted with water several times, dried, evaporated, and the base (oil) dissolved in ethanol. After addition of ethanolic hydrochloric acid, the dihydrochloride precipitates. M.p. 192°-195° (decompn.).

Workup

  1. waitleft
  2. customThereafter the solution is evaporated
  3. extractionThe chloroform phase is extracted with water several times
  4. customdried
  5. customevaporated
  6. dissolutionthe base (oil) dissolved in ethanol
  7. additionAfter addition of ethanolic hydrochloric acid
  8. customthe dihydrochloride precipitates

Sources & evidence

ORD record
ord-93ea1b543ee84bc8bbf2053eb2c2ed9c
Source dataset
uspto-grants-1976_01
Patent number
US03933805

Reaction notes

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