Dimethylamine → 2-Dimethylamino-2-(2-pyrimidyl)acetonitrile

HRID 1580567Notes

Reaction equation

HRID 1580567 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH:7]=O.[CH3:9][NH:10][CH3:11].[C-:12]#[N:13].[K+].O>CCOCC>[CH3:9][N:10]([CH3:11])[CH:7]([C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:12]#[N:13]

Participants

6

Reactant 4

HCID 674DimethylamineHCID 962WaterHCID 9032Potassium CyanideHCID 13751953Pyrimidine-2-carbaldehyde

Product 1

HCID 215630332-Dimethylamino-2-(2-pyrimidyl)acetonitrile

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 27.0 g. of 2-pyrimidinecarboxaldehyde and 11.3 g. of dimethylamine (neutralized with hydrochloric acid) is added, with stirring and cooling, 17.9 g. of potassium cyanide in a small amount of water. The mixture is allowed to stand overnight and ether is added. Concentrating and distilling the residue gives 2-dimethylamino-2-(2-pyrimidyl)acetonitrile.

Workup

  1. temperaturecooling
  2. concentrationConcentrating
  3. distillationdistilling the residue

Sources & evidence

ORD record
ord-916f2852efe5406cb9fea6621834eb41
Source dataset
uspto-grants-1976_01
Patent number
US03933811

Reaction notes

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