5-Amino-3-methylisoxazole → HCID 68134469, compound

HRID 1580581Notes

Reaction equation

HRID 1580581 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([NH2:7])[O:4][N:3]=1.[CH2:8]([O:10][C:11](=[O:20])[CH2:12][C:13]([CH:15]=[CH:16]OCC)=[O:14])[CH3:9]>>[CH2:8]([O:10][C:11](=[O:20])[CH2:12][C:13]([CH:15]=[CH:16][NH:7][C:5]1[O:4][N:3]=[C:2]([CH3:1])[CH:6]=1)=[O:14])[CH3:9]

Participants

3

Reactant 2

HCID 845905-Amino-3-methylisoxazoleHCID 54463595Ethyl ethoxymethyleneacetoacetate

Product 1

HCID 68134469HCID 68134469, compound

Procedure

98 g. of 3-methyl-5-aminoisoxazole (1 mol.) and 186 g. of ethoxymethyleneacetoacetic acid ethyl ester (1 mol.) are heated with stirring for 45 minutes at 130°. After this period, ethanol is removed under reduced pressure. The residue solidifies on cooling and is recrystallized from ethanol, m.p. 93°-95°, yield 208 g. (87%).

Workup

  1. waitAfter this period
  2. customethanol is removed under reduced pressure
  3. temperatureon cooling
  4. customis recrystallized from ethanol, m.p. 93°-95°, yield 208 g

Sources & evidence

ORD record
ord-28a9c23bf6aa4bd49f3bc075efad0b3a
Source dataset
uspto-grants-1976_01
Patent number
US03933823

Reaction notes

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