5-Amino-3-methylisoxazole → HCID 68134469, compound

Participants

Reaction Steps

98 g. of 3-methyl-5-aminoisoxazole (1 mol.) and 186 g. of ethoxymethyleneacetoacetic acid ethyl ester (1 mol.) are heated with stirring for 45 minutes at 130°. After this period, ethanol is removed under reduced pressure. The residue solidifies on cooling and is recrystallized from ethanol, m.p. 93°-95°, yield 208 g. (87%).

Provenance & Evidence