反应详情

A mixture of 2-amino-4-chloro-6-hydroxy-5-nitropyrimidine (III) (Hal = Cl) (1.53 g), 3-amino-1-(p-methoxy)phenoxy-3-methylbutan-2-one oxime hydrochloride (IV) (2.2 g) and dry triethylamine (1.70 g) in dry ethanol (20 ml) was refluxed for 2 hours. The mixture was cooled, water (50 ml) was added, and the resulting precipitate was filtered off and dried. Recrystallisation from a mixture of water and ethanol gave the nitropyrimidine oxime (II) (1.4 g, yield 48%) as pale yellow crystals, m.p. 242° (decomp.).

1. temperaturewas refluxed for 2 hours
2. temperatureThe mixture was cooled
3. filtrationthe resulting precipitate was filtered off
4. customdried
5. customRecrystallisation
6. additionfrom a mixture of water and ethanol